Parental Behavior

 

1. Neural basis of parental care
2. Molecular basis of parental care
3. Our recent study on MPOA signaling




1. Neural basis of parental care

Neural basis of parental care

<Evidence>
1) MPOA lesion specifically destroy parental behavior
(Numan, 1974; Terkel et al, 1979; Kalinichev et al., 2000)

2) Parental care induces c-Fos and FosB in MPOA
(Calamandrei and Keverne, 1994; Numan and Numan, 1994; Li et al., 1999)



2. Molecular basis of parental care

Molecular basis of parental care



3. Our recent study on MPOA signaling

Our recent study on MPOA signaling

ERK signaling cascade has been implicated in activity-dependent synaptic plasticity, such as associative learning and psychostimulant administration. Parental memory formation (Bridges, 1996; Bridges and Scanlan, 2005) might also involve synaptic plasticity in the MPOAd.

The dual roles of FosB in MPOAd neurons could be;
1) deactivation of the neurons by providing negative feedback to the upstream Ca2+/RTK-ERK signaling
2) possible structural remodeling through Rad, an RGK-family small GTP binding protein, to enhance the response of MPOAd neurons to pup exposure in future.

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