Curriculum Vitae

Kumi Ozaki KURODA.

Office:   Laboratory for Affiliative Social Behavior 

              RIKEN Brain Science Institute

              2-1 Hirosawa, Wako-shi, Saitama, JAPAN

EDUCATION

B.S.      1992, Kyoto University (Physics)

M.D.      1997, Osaka University (Medicine)

Ph.D.     2002, Osaka University Graduate School of Medicine (Molecular biology)

 

PROFESSIONAL EXPERIENCE

1997-1998           Intern, Dept. Psychiatry, Osaka University Hospital

1999-2002           Research fellow, the Japan Society for the Promotion of Science

2002-2004           Postdoctoral fellow, Dept. Neuroscience and psychiatry, McGill University, Canada

2004-2007           Special Postdoctoral Researcher, RIKEN Brain Science Institute

2007-2008           Research scientist, RIKEN Brain Science Institute

2008- 2014          Unit Leader of Kuroda Research Unit for Affiliative Social Behavior, RIKEN Brain Science Institute

2015-present   Team Leader of Laboratory for Affliative Social Behavior, , RIKEN Brain Science Institute

AWARDS AND HONORS

1999-2002           DC-1 Research Fellowship of the Japan Society for Promotion of Science

2002-2005           Long-term Fellowship of the Human Frontier Science Program

SELECTED RESEARCH PUBLICATIONS

1. Ozaki, K., Tanaka, K., Imamura, H., Hihara, T., Kameyama, T., Nonaka, H., Hirano, H., Matsuura, Y. & Takai, Y. Rom1p and Rom2p are GDP/GTP exchange proteins (GEPs) for the Rho1p small GTP binding protein in Saccharomyces cerevisiae. EMBO J 15, 2196-207. (1996).

2. Hirano, H., Tanaka, K., Ozaki, K., Imamura, H., Kohno, H., Hihara, T., Kameyama, T., Hotta, K., Arisawa, M., Watanabe, T., Qadota, H., Ohya, Y. & Takai, Y. ROM7/BEM4 encodes a novel protein that interacts with the Rho1p small GTP-binding protein in Saccharomyces cerevisiae. Mol Cell Biol 16, 4396-403. (1996).

3. Kikyo, M., Tanaka, K., Kamei, T., Ozaki, K., Fujiwara, T., Inoue, E., Takita, Y., Ohya, Y. & Takai, Y. An FH domain-containing Bnr1p is a multifunctional protein interacting with a variety of cytoskeletal proteins in Saccharomyces cerevisiae. Oncogene 18, 7046-54. (1999).

4. Tachibana, K., Nakanishi, H., Mandai, K., Ozaki, K., Ikeda, W., Yamamoto, Y., Nagafuchi, A., Tsukita, S. & Takai, Y. Two cell adhesion molecules, nectin and cadherin, interact through their cytoplasmic domain-associated proteins. J Cell Biol 150, 1161-76. (2000).

5. Ozaki-Kuroda, K., Yamamoto, Y., Nohara, H., Kinoshita, M., Fujiwara, T., Irie, K. & Takai, Y. Dynamic localization and function of Bni1p at the sites of directed growth in Saccharomyces cerevisiae. Mol Cell Biol 21, 827-39. (2001).

6. Ozaki-Kuroda, K., Nakanishi, H., Ohta, H., Tanaka, H., Kurihara, H., Mueller, S., Irie, K., Ikeda, W., Sakai, T., Wimmer, E., Nishimune, Y. & Takai, Y. Nectin couples cell-cell adhesion and the actin scaffold at heterotypic testicular junctions. Curr Biol 12, 1145-50. (2002).

7. Okabe, N., Shimizu, K., Ozaki-Kuroda, K., Nakanishi, H., Morimoto, K., Takeuchi, M., Katsumaru, H., Murakami, F. & Takai, Y. Contacts between the commissural axons and the floor plate cells are mediated by nectins. Dev Biol 273, 244-56 (2004).

8. Kuroda K.O., Meaney M.J., Uetani N., Fortin Y., Ponton A., Kato T. ERK-FosB signaling in dorsal MPOA neurons plays a major role in the initiation of parental behavior in mice. Mol Cell Neurosci, 36:121-131. (2007)

9.  Kuroda K.O., Meaney M.J., Uetani N., Kato T. Neurobehavioral basis of the impaired nurturing in mice lacking the immediate early gene FosB. Brain Res, 1211:57-71. (2008)

10. Kuroda KO, Ornthanalai VG, Kato T, Murphy NP. FosB null mutant mice show enhanced methamphetamine neurotoxicity: potential involvement of FosB in intracellular feedback signaling and astroglial function. Neuropsychopharmacology 35(3):641-55. (2010)

11. Tsuneoka Y., Maruyama T., Yoshida S., Nishimori K., Kato T., Numan M., and Kuroda K.O. Functional, anatomical, and neurochemical differentiation of medial preoptic area subregions in relation to maternal behavior in the mouse. J Comp Neurol, 521, 1633-63. (2013) (e-pub ahead: 2012)

12. Tachikawa K.S., Yoshihara Y., and Kuroda K.O. Behavioral transition from attack to parenting in male mice: a crucial role of the vomeronasal system. J Neurosci, 33, 5120-6. (2013)

13. Esposito G.*, Yoshida S.*, Ohnishi R., Tsuneoka Y., Rostagno M.C., Yokota S., Okabe S., Kamiya K., Hoshino M., Shimizu M., Venuti P., Kikusui T., and Kato T. and Kuroda K.O. Infant calming responses during maternal carrying in humans and mice. Curr Biol, 23, 739-745. *Equal contribution. (2013)

14. Yoshida S., Esposito G., Ohnishi R., Tsuneoka Y., Okabe S., Kikusui T., Kato T., and Kuroda K.O. Transport Response is a filial-specific behavioral response to maternal carrying in C57BL/6 mice. Front Zool, 10:#50 (2013)

15. Tsuneoka Y, Tokita K, Yoshihara C, Amano T, Esposito G, Huang AJ, Yu LM, Odaka Y, Shinozuka K, McHugh TJ, Kuroda KO “Distinct preoptic-BST nuclei dissociate paternal and infanticidal behavior in mice.”, EMBO Journal, 34(21), 2652-70 (2015)

 

 

REVIEW ARTICLES (English)

Cameron, N.M., Champagne, F.A., Parent, C., Fish, E.W., Ozaki-Kuroda, K. & Meaney, M.J. The programming of individual differences in defensive responses and reproductive strategies in the rat through variations in maternal care. Neurosci Biobehav Rev 29, 843-65 (2005).

Kuroda K.O., Neurobiological basis of parent-infant relationship. Preface.Prog Neuropsychopharmacol Biol Psychiatry, 35(5), 1165-6 (2011)

Kuroda KO, Tachikawa K, Yoshida S, Tsuneoka Y, and Numan M. Neuromolecular basis of parental behavior in laboratory mice and rats: with special emphasis on technical issues of using mouse genetics. Prog Neuro-psychopharmacol Biol Psychiatry 35(5), 1205-31 (2011)

Esposito G., Yoshida S., Venuti P., and Kuroda K.O. Three lessons from Philip Teitelbaum and their application to studies of motor development in humans and mice. Behav Brain Res, 231, 366-70 (2012)

Kuroda K.O., and Numan M. The medial preoptic area and the regulation of parental behavior., Neurosci Bulletin, 30(5), 863-5 (2014)

 

BOOK CHAPTERS(English)

Kuroda, K.O. and Tsuneoka Y., Assessing postpartum maternal care, alloparental behavior, and infanticide in mice: with notes on chemosensory influences. Methods Mol Biol, 1068, 331-47 (2013)


REVIEW ARTICLES (Japanese)

黒田公美吉田さちね 「親に運ばれるときに子が示す協調的反応「輸送反応」の意義と神経機構.」心身医学 2015、 55(8), 958-966

黒田公美 「 父性愛と母性愛」生体の科学 2015, 66(1), 58-65

黒田公美, 吉田さちね & Esposito, G.「親に対する子の愛着の脳神経基盤」 分子精神医学 2013, 13, 278-286

黒田公美、大西竜子& 恒岡洋右 「マウスの養育(子育て)行動とその異常:スクリーニングのためのプロトコル」 実験医学増刊 2012, 30, 2012-2111

黒田公美 「視床下部-視索前野複合体」 分子精神医学 2009, Vol. 9, 54-59

黒田公美 「哺乳類養育行動とその異常のメカニズム」 精神医学 2008、Vol.50, No.4, 387-392

黒田公美 「養育行動とその異常の分子機構」 実験医学増刊 2007、Vol.25, No.13, 2093-2098

黒田公美 「養育と乳幼児の発達」 学術の動向 2006、Vol.11, No.11, 54-55

黒田公美 「母子関係が児の精神発達に与える影響」 臨床精神医学 2004, Vol.33, No.11, 1423-1431

黒田公美 「母性行動の神経生物学的基盤」 分子神経医学 2004、Vol.4, No.4, 296-300

尾崎公美、高井義美 「低分子量Gタンパク質---その機能と作用機構」(羊土社) 実験医学増刊 1999, Vol. 17, No. 14, 1715-1721

BOOK CHAPTERS (Japanese)

黒田公美 「養育と乳幼児の発達」 (日本学術協力財団) 『学術会議叢書14:性差とは何か』 2008, 181-198

黒田(尾崎)公美、的崎尚、高井義美 「第3章 低分子量GTP結合タンパク質」 (日本生化学会編) 『シリーズ・バイオサイエンスの新世紀(9)シグナル伝達』2002 (ISBN:4320055608)